Zonulin Marker Stool Test – At-Home Intestinal Permeability Test

Zonulin Stool Test by Diagnostic Solutions – At-Home Targeted Assessment of Intestinal Permeability (Leaky Gut)

Zonulin is the primary protein that regulates the tight junctions of the intestinal lining — the gatekeepers that determine what passes from the gut into the bloodstream. When zonulin is elevated, those tight junctions loosen, increasing intestinal permeability (commonly called “leaky gut”) and allowing partially digested food particles, toxins, and microbial byproducts to enter systemic circulation.

This can trigger immune activation, chronic inflammation, and a cascade of downstream symptoms that are often difficult to trace back to the gut. First identified in research on celiac disease, elevated zonulin has since been linked to a broad range of gastrointestinal, immune, autoimmune, and metabolic conditions.

This standalone stool test offers a focused, convenient way to assess this single critical marker — without running a full stool panel.

Key Benefits

• ✅ Directly measures zonulin — the primary leaky gut biomarker — zonulin is the only known physiological regulator of intestinal tight junctions; elevated stool zonulin is the most direct available marker of increased intestinal permeability
• ✅ At-home stool collection — no clinic visit required — kit ships directly to you with easy-to-follow collection instructions and pre-paid return shipping to the lab
• ✅ Focused, targeted assessment — a single-marker test for those who want a clear answer on gut barrier function without the cost or complexity of a full stool panel
• ✅ Results in approximately 2 weeks — delivered securely to your client portal once the lab completes analysis
• ✅ Linked to a wide range of conditions in research — elevated zonulin has been associated with celiac disease, IBS, IBD, food sensitivities, autoimmune conditions, metabolic syndrome, and systemic inflammation
• ✅ Useful for monitoring gut barrier health over time — retest after dietary changes, supplement protocols, or gut healing interventions to track progress objectively
• ✅ Optional 30-minute consultation available — add expert guidance on your results and a written follow-up summary with next steps; select the consultation variant at checkout

Who This Test Is For

• Those suspecting leaky gut or intestinal permeability — if you’ve heard the term “leaky gut” and want objective data rather than guesswork, zonulin is the most direct available stool marker
• Chronic digestive symptoms — bloating, gas, food sensitivities, loose stools, or abdominal discomfort that hasn’t resolved with standard approaches
• Immune and autoimmune concerns — intestinal permeability is a proposed mechanism in autoimmune conditions; zonulin testing can help identify whether gut barrier dysfunction is a contributing factor
• Ongoing inflammation or systemic symptoms — fatigue, brain fog, skin issues, or joint discomfort that may have a gut-origin component
• Those monitoring gut healing progress — retesting zonulin after a gut-healing protocol (dietary changes, probiotics, L-glutamine, etc.) provides objective data on whether the intervention is working
• Those who’ve already run a GI-MAP® — zonulin is available as an add-on to the GI-MAP; this standalone test is ideal for those who want to isolate and track this single marker between full panels
• ⚠️ Not available to New York State residents — due to state laboratory regulations, this test cannot be shipped to or processed for NY residents

What’s Included

• At-home stool collection kit shipped directly to you
• Easy-to-follow collection instructions
• Pre-paid return shipping to the laboratory
• Laboratory analysis of stool zonulin levels
• Secure digital delivery of results via your client portal (~2 weeks after lab receipt)

What’s Not Included

• This is a standalone zonulin marker only — does not assess pathogens, parasites, digestive enzymes, inflammatory markers, or hormone markers
• Results are informational; interpretation and next-step guidance require adding a consultation

Optional: Add a 30-Minute Consultation

Select “Add 30 Minute Consultation” at checkout to include a 30-minute results review with a written follow-up summary and personalized next-step recommendations. Ideal for those who want expert guidance on what their zonulin result means and what to do about it.

Looking for a more comprehensive gut health assessment? Consider the GI-MAP® DNA Stool Test — a full stool panel that includes pathogens, parasites, digestive markers, immune markers, and optional zonulin add-on.

⚠️ Important Notes

This test is not available to residents of New York State due to state laboratory regulations. Results are informational and do not constitute a medical diagnosis. Consult your healthcare professional before making any changes to your diet, supplements, or treatment plan based on test results. Questions about whether this test is right for you? Contact our support team — we’re happy to help.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.