Pyridoxal 5'-Phosphate (P5P) by Thorne – Active B6 | 180 Caps

Pyridoxal 5’-Phosphate (P5P) by Thorne® delivers 33.8mg of P5P per capsule — the most bioactive, pre-converted form of vitamin B6 — bypassing the liver conversion step required by standard pyridoxine supplements. This makes it the preferred B6 form for individuals with compromised liver function or those who need guaranteed bioavailability.* Thorne is one of the most trusted names in pharmaceutical-grade supplementation, used by practitioners and professional athletes worldwide.

Key Benefits

• ✅ Active, pre-converted B6 (P5P) — no liver conversion required; immediately bioavailable for cellular use*
• ✅ Neurotransmitter synthesis — P5P is essential for producing serotonin, dopamine, GABA, and other key brain chemicals*
• ✅ Homocysteine metabolism — facilitates the breakdown of homocysteine to taurine and cysteine, supporting cardiovascular health*
• ✅ Hormone metabolism & PMS support — supports the metabolic pathways that process hormones, benefiting women with PMS symptoms*
• ✅ Myelin sheath formation — vital for the protective sheath surrounding nerve cells, supporting neurological function*
• ✅ Hemoglobin & intrinsic factor production — supports red blood cell formation and B12 absorption*
• ✅ Energy production — essential for amino acid transformation and energy metabolism*
• ✅ Not derived from yeast — suitable for those with yeast sensitivities
• ✅ 180 capsules — 60–180 day supply depending on dose

Who It’s For

• Those following HTMA or mineral balancing protocols where B6/P5P is recommended for adrenal support or copper metabolism*
• Individuals with compromised liver function who cannot efficiently convert pyridoxine to P5P*
• Women seeking hormone metabolism and PMS symptom support*
• Those supporting neurotransmitter production, mood, or neurological health*
• Anyone wanting the most bioavailable form of vitamin B6 from a practitioner-trusted brand

Why P5P Instead of Pyridoxine?

Standard vitamin B6 supplements use pyridoxine, which must be converted to pyridoxal 5’-phosphate (P5P) in the liver before the body can use it.* Individuals with compromised liver function, genetic variants affecting B6 metabolism, or high B6 demand may not convert pyridoxine efficiently — leaving them at risk of functional B6 deficiency even when supplementing.* Thorne’s P5P delivers the active form directly, ensuring reliable bioavailability regardless of conversion capacity.*

Supplement Facts

Serving Size: 1 Capsule  |  Servings per Container: 180

Per Serving:

• Vitamin B6 (as Pyridoxal 5’-Phosphate) — 33.8mg

Other Ingredients: Calcium laurate, hypromellose capsule, microcrystalline cellulose, silicon dioxide.

Suggested Use

Take 1 capsule one to three times daily, or as recommended by your healthcare practitioner.

Warning: Contraindicated in individuals with a history of hypersensitivity to any ingredient. Consult your health professional before use if pregnant. Keep out of reach of children.

Pyridoxal 5’-Phosphate (P5P) — 180 Capsules — 33.8mg Active Vitamin B6 — by Thorne®