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Source Naturals

TMG Trimethylglycine 750mg by Source Naturals – 60 Tablets

TMG Trimethylglycine 750mg by Source Naturals – 60 Tablets

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Trimethylglycine (Anhydrous Betaine) 750mg – Methylation & Cardiovascular Support

TMG (trimethylglycine), also known as anhydrous betaine, is a key methyl donor found in a variety of plant and animal sources. It plays a central role in converting homocysteine to methionine — a critical step for cardiovascular health, liver function, and balanced mood via SAM (S-adenosylmethionine) production.


Key Benefits

  • Supports healthy homocysteine metabolism — helps maintain normal homocysteine levels, a key marker for cardiovascular and cognitive health
  • Promotes methylation — TMG is a primary methyl donor that supports the methylation cycle, essential for DNA repair, detoxification, and neurotransmitter production
  • Raises SAM (S-adenosylmethionine) levels — SAM supports a balanced emotional state and is involved in over 200 enzymatic reactions in the body
  • Liver protective — shown in animal studies to help protect the liver and support healthy liver function
  • Synergistic with methylation cofactors — works best alongside vitamin B-6, B-12, and folate for comprehensive methylation support
  • Vegetarian & clean label — no yeast, dairy, egg, gluten, corn, soy, wheat, sugar, starch, salt, preservatives, or artificial additives

Who It's For

  • HTMA and mineral balancing protocol users — TMG is a key methyl donor commonly recommended in copper and heavy metal detox protocols to support the methylation cycle
  • Anyone with elevated homocysteine looking for a targeted, evidence-informed supplement to support cardiovascular and cognitive health
  • Methylation support seekers — those with MTHFR variants or other methylation challenges who need additional methyl donor support beyond folate and B12
  • Liver health and detox protocol users — supporting SAM production and liver protection during active detox phases
  • Mood and cognitive wellness — those looking to support a balanced emotional state through SAM pathway optimization

Supplement Facts

Serving Size: 1 Tablet
Servings Per Container: 60

Ingredient Amount Per Serving
Trimethylglycine (TMG, Anhydrous Betaine) 750 mg
Calcium (from dibasic calcium phosphate) 43 mg
Protein 1 g

Other Ingredients: Dibasic calcium phosphate, stearic acid, microcrystalline cellulose, modified cellulose gum, magnesium stearate, silica.

Free of: Yeast, dairy, egg, gluten, corn, soy, wheat, sugar, starch, salt, preservatives, and artificial color, flavor, or fragrance. Suitable for vegetarians.


Suggested Use

Daily maintenance: 1–2 tablets per day.
To support lower homocysteine levels: 2–4 tablets per day.
For enhanced methylation support: Take alongside vitamin B-6, B-12, and folic acid as part of a comprehensive methyl donor protocol.


⚠️ Warning

If you are pregnant, may become pregnant, or are breastfeeding, consult your healthcare professional before using this product. Do not use if either tamper-evident seal is broken or missing. Keep out of the reach of children.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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